# mSphere of Influence: Complement activity beyond systemic circulation—implications in the context of infections

## TL;DR

This article discusses how research on the complement system has influenced ongoing studies of immune regulation in mucosal and systemic contexts.

## Contribution

The paper highlights the impact of prior research on the author's investigation into complement regulation and immunity.

## Key findings

- The work of Kemper, Kulkarni, and Kasper has shaped the author's understanding of complement regulation.
- The article emphasizes the importance of both cell-intrinsic and extrinsic complement regulation in immunity.

## Abstract

Jigar V. Desai works in the field of immunology, studying the mucosal and systemic complement systems and their roles in regulating the immune response. In this mSphere of Influence article, he reflects on how the papers by the Kemper, Kulkarni, and Kasper laboratories made an impact on his ongoing work investigating the cell-intrinsic and extrinsic regulation of complement and studying its impacts on mucosal and systemic immunity.