# Retraction Note: β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma

**Authors:** Yanwei Lu, Xudong Li, Hongli Liu, Jun Xue, Zhen Zeng, Xiaorong Dong, Tao Zhang, Gang Wu, Kunyu Yang, Shuangbing Xu

PMC · DOI: 10.1038/s41388-025-03344-w · Oncogene · 2025-03-17

## Full-text entities

- **Genes:** BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase) [NCBI Gene 8945] {aka BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP}, LZTS2 (leucine zipper tumor suppressor 2) [NCBI Gene 84445] {aka LAPSER1}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}
- **Diseases:** tumorigenesis (MESH:D063646), metastasis (MESH:D009362), hepatocellular carcinoma (MESH:D006528)

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Source: https://tomesphere.com/paper/PMC11932924