# Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

## TL;DR

This paper presents a new electrochemical method to synthesize 2-aminoprolines from N-acetylamino malonic acid monoesters.

## Contribution

A novel electrochemical approach for the synthesis of protected 2-aminoproline derivatives is introduced.

## Key findings

- Electrochemical decarboxylative amidation was successfully used to produce N-sulfonyl, N-benzoyl, and N-Boc-protected 2-aminoproline derivatives.
- The reaction proceeds efficiently in an undivided cell under constant current in aqueous acetonitrile.
- The method uses readily available N-acetylamino malonic acid monoesters as starting materials.

## Abstract

The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds in an undivided cell under constant current conditions in aqueous acetonitrile and provides access to N-sulfonyl, N-benzoyl, and N-Boc-protected 2-aminoproline derivatives.