# Crosstalk between Tumor Cells and Neural Signals in Neuroendocrine Carcinoma Metastasis: Communication Hijacking Based Perspective

## TL;DR

This review explores how neuroendocrine carcinoma cells hijack neural signals to promote tumor growth and metastasis, highlighting the bidirectional communication between tumor cells and neurons.

## Contribution

The paper provides a comprehensive overview of crosstalk mechanisms in neuroendocrine carcinoma metastasis from a neuroscience perspective.

## Key findings

- NEC cells dynamically regulate neuronal lineage markers to create a tumor-supportive microenvironment.
- Bidirectional interactions between tumor cells and neurons enhance metastatic potential.
- Neuroscience insights reveal new directions for understanding complex tumor metastasis, especially to the brain.

## Abstract

神经内分泌癌（neuroendocrine carcinoma, NEC）为一类起源于神经内分泌细胞的恶性肿瘤。由于NEC细胞兼具神经细胞和内分泌细胞的特性，在肿瘤转移过程中可通过多种机制劫持神经元信号传导并动态调节神经元谱系标志物的表达，从而形成有利于肿瘤生长与转移的微环境。另一方面，肿瘤微环境的变化反过来也会增强神经元与肿瘤细胞的相互作用，最终协同促进NEC转移的发生。本综述介绍了癌症神经科学领域的研究进展，揭示了NEC中的神经元谱系标志物，通过介导肿瘤细胞与神经系统之间发生串扰、双向交流以及协同作用，促进肿瘤扩散转移。因此，肿瘤神经科学领域的最新研究成果，丰富了我们对肿瘤转移生物学机制的认识，为深入理解肿瘤转移，特别是脑转移的复杂生物学过程，开辟了新的研究方向。本文就肿瘤细胞与神经信号在NEC转移中的串扰作用作一综述。