# Research status of the relationship between microecological imbalance and lung cancer

## TL;DR

This review explores how imbalances in the body's microecology, especially in the gut and lungs, are linked to lung cancer and could help in early diagnosis and treatment.

## Contribution

The paper provides a focused analysis on the role of gut, oral, and respiratory microbiota in lung cancer progression and therapy response.

## Key findings

- Microbiota dysbiosis is linked to lung cancer development and affects treatment outcomes.
- Gut, oral, and lower respiratory tract microbiota show significant correlations with lung cancer.
- Microecology-centered approaches may offer new diagnostic and therapeutic strategies for lung cancer.

## Abstract

Microecology refers to the ecosystem formed by human and microbial communities in the process of co-evolution, the microecological imbalance is associated with occurrence and development of multiple diseases, including lung cancer. In this review, we detailedly summarized the concept and roles of microecology, the relationship between microecology and human diseases, and related techniques in microecology studies. Importantly, we specially analyzed the correlations between microecology and lung cancer by focusing on gut microbiota, oral microbiota and lower respiratory tract microbiota, and further evaluated the effects of microbiota dysbiosis on chemotherapy and immunotherapy efficacy in lung cancer. At last, we discussed the potential mechanisms by which dysregulated microbiota promotes the genesis and development of lung cancer. Microecology-centered detection and intervention will improve the early diagnosis of lung cancer and provide new targets for the treatment of lung cancer.