# Phlegmasia Cerulea Dolens in a 21-Year-Old Female Patient Following Depo-Provera Injection: A Case Report

## TL;DR

A 21-year-old woman developed a rare blood clot condition after a Depo-Provera injection, requiring urgent treatment and highlighting the need for careful monitoring.

## Contribution

This case report highlights a potential link between Depo-Provera and phlegmasia cerulea dolens, a rare form of deep vein thrombosis.

## Key findings

- The patient developed extensive DVT and pulmonary embolisms following a Depo-Provera injection.
- Multidisciplinary interventions including thrombectomy and thrombolysis led to favorable outcomes.
- The case underscores the importance of prompt diagnosis and management in similar cases.

## Abstract

Phlegmasia cerulea dolens (PCD) is a rare and severe form of deep vein thrombosis (DVT) associated with limb ischemia. We present the case of a 21-year-old female patient who presented with lower extremity numbness, pain, and swelling, accompanied by pleuritic chest pain and shortness of breath. She had a recent history of receiving a Depo-Provera shot for birth control. Diagnostic assessments revealed an extensive femoral-to-popliteal DVT and bilateral pulmonary embolisms. The patient underwent a series of interventions, including thrombectomy, catheter-directed thrombolysis, and repeat thrombectomy with venoplasty. She was discharged on anticoagulation therapy and showed favorable outcomes during her hospital stay. This case highlights the potential association between Depo-Provera use and the development of PCD, emphasizing the importance of prompt diagnosis, multidisciplinary management, and follow-up care.