# IgA Vasculitis (Henoch-Schönlein Purpura) in a Seven-Year-Old Female Child With Recurrent Respiratory Infections

**Authors:** Mariam Sleem, Sheridan Padgett, Ahmed Rezk

PMC · DOI: 10.7759/cureus.79360 · Cureus · 2025-02-20

## TL;DR

A seven-year-old girl with a history of strep throat developed IgA vasculitis, highlighting the need for early diagnosis and treatment in children.

## Contribution

The case highlights potential links between prematurity and susceptibility to IgA vasculitis in pediatric patients.

## Key findings

- The patient exhibited symptoms including purpuric rash, joint pain, and hematuria consistent with IgA vasculitis.
- Despite treatment with azithromycin and prednisolone, the patient's condition worsened with new symptoms.
- The case emphasizes the importance of early recognition and management of IgA vasculitis in children.

## Abstract

A seven-year-old female child presented with a purpuric rash, joint pain, and a recent history of streptococcal pharyngitis. Initial symptoms included fever, throat pain, and vomiting, for which she received amoxicillin. Following treatment, the patient developed a rash and joint pain, prompting further evaluation. The physical examination revealed erythematous, edematous, and purpuric lesions on the extremities, along with periarticular swelling in the knees and ankles. Laboratory investigations showed hematuria, raising concerns for differential diagnoses, including IgA vasculitis, acute urticaria, acute glomerulonephritis, and idiopathic thrombocytopenic purpura. Treatment was adjusted with azithromycin and prednisolone. Despite these interventions, the patient's condition worsened, with new symptoms including fatigue, abdominal pain, and the spread of purpuric lesions. Although hospital admission was recommended, the patient's mother opted for care at an alternative facility. This case underscores the importance of early recognition and management of IgA vasculitis in pediatric patients and highlights potential links between prematurity and susceptibility to this condition.

## Linked entities

- **Chemicals:** amoxicillin (PubChem CID 33613), azithromycin (PubChem CID 447043), prednisolone (PubChem CID 5755)
- **Diseases:** IgA vasculitis (MONDO:0019167), strep throat (MONDO:0021783), idiopathic thrombocytopenic purpura (MONDO:0008558)

## Full-text entities

- **Diseases:** throat pain (MESH:D010146), fatigue (MESH:D005221), Purpura (MESH:D011693), abdominal pain (MESH:D015746), IgA Vasculitis (MESH:D011695), acute glomerulonephritis (MESH:D000208), fever (MESH:D005334), joint pain (MESH:D018771), urticaria (MESH:D014581), idiopathic thrombocytopenic purpura (MESH:D016553), Respiratory Infections (MESH:D012141), hematuria (MESH:D006417), purpuric rash (MESH:D005076), vomiting (MESH:D014839), streptococcal pharyngitis (MESH:D013290), purpuric lesions (MESH:C537186), swelling (MESH:D004487)
- **Chemicals:** azithromycin (MESH:D017963), prednisolone (MESH:D011239), amoxicillin (MESH:D000658)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11930766/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC11930766/full.md

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Source: https://tomesphere.com/paper/PMC11930766