# Transmantle heterotopia associated with agenesis of the corpus callosum in a patient with Parkinson: A case report

**Authors:** Mattia Russel Pantalone, Stanislav Beniaminov, Daniel Martin Munoz, Francesca De Luca

PMC · DOI: 10.1016/j.radcr.2025.02.034 · Radiology Case Reports · 2025-03-08

## TL;DR

This case report describes a patient with brain malformations and Parkinson's disease, highlighting diagnostic challenges.

## Contribution

The novelty lies in presenting a rare case linking agenesis of the corpus callosum and Parkinson's in an elderly patient.

## Key findings

- The patient exhibited agenesis of the corpus callosum and transmantle heterotopia.
- The case highlights diagnostic difficulties in elderly patients with neurodegenerative diseases.
- Such brain malformations may coexist with Parkinson's disease, requiring careful evaluation.

## Abstract

Congenital malformations of the brain that can manifest at different ages with a wide spectrum of neurological symptoms. Although they have been described in adults, their relevance in the elderly in relation to other neurodegenerative disease is not well defined. Here we described the case of a man with the agenesis of the corpus callosum and transmantle heterotopia being diagnosed with Parkinson and we analyze the diagnostic challenges this case presented.

## Full-text entities

- **Diseases:** Transmantle heterotopia (MESH:D054091), neurodegenerative disease (MESH:D019636), agenesis of the corpus callosum (MESH:D061085), Parkinson (MESH:D010302), Congenital malformations of the brain (MESH:D020785)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11930512/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC11930512/full.md

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Source: https://tomesphere.com/paper/PMC11930512