# Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

**Authors:** Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley

PMC · DOI: 10.1016/j.isci.2025.112152 · 2025-03-05

## Full-text entities

- **Genes:** GRM5 (glutamate metabotropic receptor 5) [NCBI Gene 2915] {aka GPRC1E, MGLUR5, PPP1R86, mGlu5}, GRIK2 (glutamate ionotropic receptor kainate type subunit 2) [NCBI Gene 2898] {aka EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6}, KAR [NCBI Gene 8083], KARS1 (lysyl-tRNA synthetase 1) [NCBI Gene 3735] {aka CMTRIB, DEAPLE, DFNB89, KARS, KARS2, KRS}, GAPDH (glyceraldehyde-3-phosphate dehydrogenase) [NCBI Gene 2597] {aka G3PD, GAPD, HEL-S-162eP}, GRM1 (glutamate metabotropic receptor 1) [NCBI Gene 2911] {aka GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13}, PRRT2 (proline rich transmembrane protein 2) [NCBI Gene 112476] {aka BFIC2, BFIS2, DSPB3, DYT10, EKD1, FICCA}
- **Chemicals:** KA (-)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11927740/full.md

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Source: https://tomesphere.com/paper/PMC11927740