# Splenic Artery Embolization as a Primary Treatment for Hereditary Spherocytosis: A Case Report

## TL;DR

A patient with hereditary spherocytosis showed improvement after a minimally invasive spleen procedure instead of surgery.

## Contribution

This case demonstrates partial splenic artery embolization as a safe alternative to splenectomy for hereditary spherocytosis.

## Key findings

- Hemoglobin levels increased from 7.7 g/dL to 11.3 g/dL after the procedure.
- Improvements in hematocrit and bilirubin levels were observed with no major complications.
- Partial splenic embolization preserved spleen function while treating the condition.

## Abstract

The primary management of hereditary spherocytosis (HS) typically involves splenectomy to prevent hemolytic crises. However, splenic artery embolization (SAE) has emerged as a promising minimally invasive alternative. We report a case of a woman in her mid-20s with severe HS who presented with chronic fatigue, anemia resistant to iron supplementation, and splenomegaly. The diagnosis was confirmed through clinical findings, osmotic fragility test, and laboratory results. A partial embolization of the lower two-thirds of the spleen was performed while preserving the function of the upper third. Post-procedure, significant improvements were observed in hemoglobin levels (rising from 7.7 g/dL to 11.3 g/dL), hematocrit, and bilirubin levels, with no major complications reported. This case highlights that partial selective splenic artery embolization (PSE) is a safe and effective non-surgical procedure that can be considered as a potential alternative to splenectomy in the management of hereditary spherocytosis. Further studies are warranted to establish its long-term efficacy.