# RETRACTION: lncRNA NEAT1/miR‐495‐3p Regulates Angiogenesis in Burn Sepsis Through the TGF‐β1 and SMAD Signaling Pathways

PMC · DOI: 10.1002/iid3.70177 · 2025-03-21

## TL;DR

This retracted paper claimed that lncRNA NEAT1/miR-495-3p regulates angiogenesis in burn sepsis via TGF-β1 and SMAD pathways, but was retracted due to scientific flaws.

## Contribution

The paper originally proposed a novel regulatory mechanism involving lncRNA NEAT1 and miR-495-3p in burn sepsis.

## Key findings

- The study reported that NEAT1/miR-495-3p influences angiogenesis in burn sepsis.
- It suggested TGF-β1 and SMAD signaling pathways are involved in this process.
- However, the findings were retracted due to methodological and result inconsistencies.

## Abstract

RETRACTION: Y. Meng, Z. Hao, H. Zhang, P. Bai, W. Guo, X. Tian and J. Xu, “lncRNA NEAT1/miR‐495‐3p Regulates Angiogenesis in Burn Sepsis Through the TGF‐β1 and SMAD Signaling Pathways,” Immunity, Inflammation and Disease 11, no. 1 (2023): e758, https://doi.org/10.1002/iid3.758.

The above article, published online on January 16, 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement the journal Editor‐in‐Chief, Marc Veldhoen; and John Wiley & Sons Ltd. The retraction has been agreed due scientific flaws and inconsistencies found in the methodology and results of this article. While the authors were able to provide some supporting data, this was not sufficient and the irregularities remain. The editors have lost confidence in the results and conclusions presented in this study. The authors disagree with the retraction.

## Linked entities

- **Genes:** NEAT1 (nuclear paraspeckle assembly transcript 1) [NCBI Gene 283131], TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040], Smox (Smad on X) [NCBI Gene 31738]

## Full-text entities

- **Genes:** NEAT1 (nuclear paraspeckle assembly transcript 1) [NCBI Gene 283131] {aka LINC00084, NCRNA00084, TP53LC15, TncRNA, VINC}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}
- **Diseases:** Inflammation (MESH:D007249), Burn Sepsis (MESH:D018805)

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Source: https://tomesphere.com/paper/PMC11926761