# Lab-in-a-Fiber detection and capture of cells

## TL;DR

A low-cost optical fiber device detects and captures labeled cells, showing potential for cancer diagnostics and in vivo cell analysis.

## Contribution

A novel lab-in-a-fiber device enables cell detection, capture, and viability for downstream analysis with minimal cost and complexity.

## Key findings

- The device successfully detected and captured fluorescently labeled cells in a suspension.
- The sampling technique reduced photobleaching, allowing extended measurement times.
- Captured cells remained viable for further analysis, demonstrating practical utility.

## Abstract

A lab-in-a-fiber component was fabricated using an optical fiber and a fiber capillary. It was used in a test suspension of fluorescently labeled and unlabeled cells and enabled detection of the labeled cells. Subsequently the labeled cells were selectively collected via suction into the capillary. A novel sampling technique reduced photobleaching of the labeled cells, extending the measurement time. The collected cells remained viable for downstream analysis. This platform’s low fabrication cost, simplicity, compatibility with standard laboratory equipment, and capacity for fully automated cell capture highlights its potential for future applications in minimally invasive sample collection and point-of-care diagnostics. We demonstrate this LiF device to showcase the capability of optical fiber technology in creating low-cost, low-complexity cancer diagnostic devices. Furthermore, the LiF device holds promise for in vivo diagnostics, facilitating cell isolation and analysis.

The online version contains supplementary material available at 10.1038/s41598-025-92585-6.