# Herpes Simplex Virus (HSV) Pneumonitis as a Late Complication of COVID-19 Infection: A Unique Case Report

**Authors:** Shirisha Pasula, Rupalakshmi Vijayan

PMC · DOI: 10.7759/cureus.79228 · Cureus · 2025-02-18

## TL;DR

A patient developed herpes simplex virus pneumonitis over a year after recovering from COVID-19, showing that late complications can occur even in immunocompetent individuals.

## Contribution

This case report presents a rare instance of delayed HSV pneumonitis following a COVID-19 infection in an otherwise healthy patient.

## Key findings

- HSV pneumonitis occurred over a year after initial COVID-19 infection.
- The patient responded to standard treatment with oral acyclovir.
- The case underscores the need for vigilance regarding late viral reactivation in post-COVID-19 patients.

## Abstract

This case report details a patient who presented with gradually worsening shortness of breath and hemoptysis over a year following her COVID-19 infection. Notably, the patient was otherwise immunocompetent. After a comprehensive evaluation, she was diagnosed with herpes simplex virus (HSV) pneumonitis. The patient was treated with oral acyclovir, which is the standard approach for managing HSV pneumonitis. This case highlights the potential for delayed HSV reactivation and the need for awareness of such complications in patients recovering from COVID-19.

## Linked entities

- **Chemicals:** acyclovir (PubChem CID 135398513)
- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** HSV pneumonitis (MESH:D006561), COVID-19 (MESH:D000086382), shortness of breath (MESH:D004417), hemoptysis (MESH:D006469)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11925227/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC11925227/full.md

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Source: https://tomesphere.com/paper/PMC11925227