# Development of venous thromboembolism and its impact on hospitalized adults with covid-19: rapid systematic review

## TL;DR

Hospitalized adults with COVID-19 are at higher risk of developing blood clots, especially in intensive care units.

## Contribution

This rapid systematic review synthesizes current evidence on the link between COVID-19 and venous thromboembolism.

## Key findings

- Hospitalized COVID-19 patients have an increased risk of developing venous thromboembolism.
- ICU patients and those with elevated D-dimer levels are at higher risk.
- Male gender is associated with a greater likelihood of VTE in hospitalized patients.

## Abstract

The association between COVID-19 and coagulation disorders has been discussed since the onset of the pandemic. Four years into the pandemic, it is crucial to organize the findings and evidence accumulated thus far. The objective of this study was to review and synthesize the available scientific evidence regarding the relationship between COVID-19 and development of venous thromboembolism (VTE). A rapid systematic review was conducted by searching two electronic databases, selecting systematic review articles that assessed the association between COVID-19 and development of VTE, such as deep vein thrombosis (DVT) or pulmonary embolism (PE). The studies indicated that hospitalized COVID-19 patients are at greater risk of developing VTE, especially those admitted to intensive care units (ICUs). Elevated D-dimer levels and male gender were also associated with increased risks.

A associação entre a covid-19 e distúrbios de coagulação é discutida desde o início da pandemia, de modo que, passados 4 anos, é importante sistematizar as descobertas e evidências encontradas até o momento. O objetivo do estudo foi revisar e sintetizar as evidências científicas disponíveis sobre a relação entre a covid-19 e o desenvolvimento de tromboembolismo venoso. Foi realizada uma revisão sistemática rápida, com a busca conduzida em duas bases de dados eletrônicas, e incluídos artigos de revisão sistemática que avaliaram a associação entre a covid-19 e o desenvolvimento de tromboembolismo venoso, como trombose venosa profunda ou embolia pulmonar. Os estudos apontaram que pacientes hospitalizados por covid-19 apresentam maior risco de desenvolver tromboembolismo venoso, especialmente os internados em unidade de terapia intensiva. Valores de Dímero D elevado e o sexo masculino também foram associados a maiores riscos.