# Onset of tics in an elderly patient undergoing androgen deprivation therapy for prostate cancer: a case report

**Authors:** Kim Madundo, Godwin Nnko, Leila Mwakipunda, Glory Makupa, Furaha Serventi

PMC · DOI: 10.1093/omcr/omae206 · Oxford Medical Case Reports · 2025-03-20

## TL;DR

An elderly man developed tics while receiving prostate cancer treatment, which resolved with medication, showing cancer therapies can cause neuropsychiatric side effects.

## Contribution

Reports a rare case of medication-induced tics in an older adult undergoing androgen deprivation therapy for prostate cancer.

## Key findings

- Tics in an elderly patient were linked to androgen deprivation therapy with Goserelin.
- Tics resolved with low-dose Risperidone without adverse effects.
- The case highlights the neuropsychiatric side effects of cancer treatments.

## Abstract

Motor and vocal tics typically manifest during childhood. Less often, tics can occur due to the use of substances or medications which raise dopamine levels. This case report describes an unusual occurrence of tics in an elderly man undergoing androgen deprivation with Goserelin for prostate cancer. Comprehensive assessments ruled out infectious, metabolic, psychiatric, and neurological conditions. The tics resolved with low-dose Risperidone, without adverse effects. This case underscores the potential for medication-induced tics in older adults, highlighting the need for increased awareness among healthcare providers regarding the neuropsychiatric effects of cancer therapies. Future research should further investigate these phenomena and their implications for treatment strategies.

## Linked entities

- **Chemicals:** Goserelin (PubChem CID 5311128), Risperidone (PubChem CID 5073)
- **Diseases:** prostate cancer (MONDO:0005159)

## Full-text entities

- **Diseases:** Motor and vocal tics (MESH:D020323), androgen (MESH:D014770), neurological (MESH:D009461), prostate cancer (MESH:D011471), neuropsychiatric (MESH:C000631768), psychiatric (MESH:D001523), cancer (MESH:D009369), infectious (MESH:D003141)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11924399/full.md

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Source: https://tomesphere.com/paper/PMC11924399