# Toxic epidermal necrolysis induced by axitinib in a patient with advanced lung adenocarcinoma

**Authors:** Na Wang, Dongkai Li, Huaiwu He, Yun Long, Dawei Liu

PMC · DOI: 10.1093/skinhd/vzae028 · Skin Health and Disease · 2025-02-14

## TL;DR

A patient with lung cancer developed a severe skin reaction called toxic epidermal necrolysis after taking axitinib, an EGFR inhibitor.

## Contribution

Highlights a rare but serious adverse effect of axitinib in lung cancer patients.

## Key findings

- Axitinib can cause toxic epidermal necrolysis in patients with lung adenocarcinoma.
- Early recognition of widespread rash is critical for managing this adverse reaction.

## Abstract

Patients taking oral EGFR inhibitors should be alert to the risk of TEN if they suddenly develop widespread rash.

## Linked entities

- **Chemicals:** axitinib (PubChem CID 3086685)
- **Diseases:** lung adenocarcinoma (MONDO:0005061), toxic epidermal necrolysis (MONDO:0019810)

## Full-text entities

- **Genes:** EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}
- **Diseases:** rash (MESH:D005076), lung adenocarcinoma (MESH:D000077192), Toxic epidermal necrolysis (MESH:D013262)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11924358/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11924358/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC11924358/full.md

---
Source: https://tomesphere.com/paper/PMC11924358