# Halogenation of arenes using alkali metal halides/Fe(NO3)3·9H2O at room temperature

## TL;DR

A new, eco-friendly method for halogenating arenes using iron nitrate and alkali metal halides at room temperature was developed.

## Contribution

The method enables efficient halodecarboxylation of anisole analogues at room temperature using Fe(NO3)3·9H2O and alkali metal halides.

## Key findings

- Electron-donating substrates gave good to excellent yields.
- Electron-withdrawing substrates gave low to moderate yields.
- The method works for gram-scale synthesis.

## Abstract

A simple, efficient and environmentally friendly methodology for the halodecarboxylation of anisole analogues using Fe(NO3)3·9H2O/KBr or NaI at room temperature was developed. In this method, most substrates with an electron-donating group afforded corresponding products in good to excellent yields, whereas those with an electron-withdrawing group afforded low to moderate yields. More importantly, this protocol was also applicable for gram-scale synthesis. It is hoped that this methodology will be highly useful in organic synthesis.

A simple, efficient and environmentally friendly methodology for the halodecarboxylation of anisole analogues using Fe(NO3)3·9H2O/KBr or NaI at room temperature was developed.