# A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients

## TL;DR

This study found that lower antioxidant levels and higher oxidative stress in dialysis patients are linked to poor maturation of blood vessels used for dialysis.

## Contribution

The study identifies serum SOD and MDA as potential biomarkers for predicting arteriovenous fistula maturation failure in hemodialysis patients.

## Key findings

- Reduced serum SOD and elevated MDA are independent risk factors for AVF maturation failure.
- The combined AUC of SOD and MDA for predicting AVF maturation failure is 0.79.
- Ultrasound measurements also showed differences between maturation success and failure groups.

## Abstract

This study was to investigate the relationship between serum superoxide dismutase (SOD) and malondialdehyde (MDA) and arteriovenous fistula (AVF) maturation in maintenance hemodialysis (MHD) patients.

A total of 120 MHD patients were divided into a maturation group (72 patients) and a maturation failure group (48 patients). General information and ultrasound data were collected and venous blood was drawn for routine blood tests. General data and serum SOD and MDA were compared. Independent variables with statistically significant (P < 0.05) differences in univariate analysis were included in multivariate logistic regression. Serum SOD and MDA in predicting maturation failure of AVF were analyzed using receiver operating characteristic curves.

The internal diameter of the cephalic vein, internal diameter of the cephalic vein after tourniquet binding, internal diameter of the radial artery, and serum SOD level were lower and serum MDA level was higher in the maturation failure group. Reduced SOD and elevated MDA were independent risk factors for maturation failure of AVF. The area under the curve (AUC) for serum SOD and MDA was 0.68 each. When combined, their AUC for predicting AVF maturation failure was 0.79.

Reduced serum SOD and increased MDA are risk factors affecting AVF maturation in MHD patients.