# ECT-induced primary open-angle glaucoma in a patient with unstable thyroid function: a case report

**Authors:** Cuiyuan Fu, Xiuzhen Yang, Kun Li

PMC · DOI: 10.3389/fpsyt.2025.1497205 · Frontiers in Psychiatry · 2025-03-05

## TL;DR

An elderly woman with schizophrenia and unstable thyroid function developed glaucoma after ECT, highlighting the need for eye pressure monitoring during treatment.

## Contribution

This case report highlights a previously undocumented risk of ECT-induced glaucoma in patients with unstable thyroid function.

## Key findings

- The patient developed primary open-angle glaucoma after three ECT sessions.
- Intraocular pressure returned to normal before and after the fourth ECT session.
- The case underscores the need for monitoring eye pressure in patients with unstable thyroid function undergoing ECT.

## Abstract

Schizophrenia is a prevalent and severe psychiatric disorder for which electroconvulsive therapy (ECT) is frequently utilized as a treatment modality. Although ECT can transiently elevate intraocular pressure, the incidence of ECT-related adverse ophthalmic events in patients with coexisting hyperthyroidism is not well documented.

In this report, we describe an elderly woman with schizophrenia and hyperthyroidism. Before undergoing ECT, she had no previous history of glaucoma, and her thyroid function was in an unstable state. After three sessions of ECT, the patient exhibited conjunctival congestion and was subsequently diagnosed with primary open-angle glaucoma, which was not treated. Her intraocular pressure normalized prior to and following the fourth ECT session, and she experienced no further ocular discomfort during subsequent treatments (fifth through eighth sessions).

Although ECT has been used in patients with coexisting psychiatric and thyroid dysfunction, there is a lack of reports addressing the risk of inducing or exacerbating glaucoma in the context of unstable thyroid function. This case emphasizes the necessity of monitoring intraocular pressure in patients with unstable thyroid function during ECT, to mitigate the risk of ocular complications.

## Linked entities

- **Diseases:** schizophrenia (MONDO:0005090), hyperthyroidism (MONDO:0004425), primary open-angle glaucoma (MONDO:0005338)

## Full-text entities

- **Diseases:** glaucoma (MESH:D005901), Schizophrenia (MESH:D012559), conjunctival congestion (MESH:D003229), hyperthyroidism (MESH:D006980), primary open-angle glaucoma (MESH:D005902), thyroid dysfunction (MESH:D013959), psychiatric (MESH:D001523)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC11920178/full.md

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Source: https://tomesphere.com/paper/PMC11920178