# Limitations of estimating antibiotic resistance using German hospital consumption data - a comprehensive computational analysis

## TL;DR

This paper shows that current hospital data in Germany is insufficient to accurately estimate how antibiotic use affects resistance, and suggests improvements for data collection.

## Contribution

The study highlights the limitations of existing data structures and proposes specific data requirements for better analysis of antibiotic resistance.

## Key findings

- Current data sets on antibiotic consumption and resistance lead to contradictory results.
- Monthly or quarterly data at the hospital department level is needed for reliable analysis.
- Improved data collection and distribution are essential for understanding resistance development.

## Abstract

For almost a century, antibiotics have played an important role in the treatment of infectious diseases. However, the efficacy of these very drugs is now threatened by the development of resistances, which pose major challenges to medical professionals and decision-makers. Thereby, the consumption of antibiotics in hospitals is an important driver that can be targeted directly. To illuminate the relation between consumption and resistance depicts a very important step in this procedure. With the help of comprehensive ecological and clinical data, we applied a variety of different computational approaches ranging from classical linear regression to artificial neural networks to analyze antibiotic resistance in Germany. These mathematical and statistical models demonstrate that the amount and particularly the structure of currently available data sets lead to contradictory results and do, therefore, not allow for profound conclusions. More effort and attention on both data collection and distribution is necessary to overcome this problem. In particular, our results suggest that at least monthly or quarterly antibiotic use and resistance data at the department and ward level for each hospital (including application route and type of specimen) are needed to reliably determine the extent to which antibiotic consumption influences resistance development.