# Development of Repetitive Mechanical Oscillation Needle-Free Injection through Electrically Induced Microbubbles

## TL;DR

A new needle-free injection method uses electrically induced microbubbles and shock waves to improve reagent delivery into tissue.

## Contribution

A novel shock wave reflection method is introduced to enhance injection depth in microbubble-based needle-free systems.

## Key findings

- Shock wave reflection improves reagent injection depth using microbubble dynamics.
- The method enhances the performance of electrically induced microbubble injection systems.
- This advancement extends the potential applications of needle-free injection technology.

## Abstract

We previously developed a novel needle-free reagent injection method based on electrically induced microbubbles. The system generates microbubbles and applies repetitive mechanical oscillation associated with microbubble dynamics to perforate tissue and introduce a reagent. In this paper, we propose improving the reagent injection depth by reflecting the shock wave through microbubble dynamics. Our results show that the developed shock wave reflection method improves the ability of the electrically induced microbubble injection system to introduce a reagent. The method extends the application potential of electrically induced microbubble needle-free injection.