# Mapping the Landscape of Magnetic Field Effects on Neural Regeneration and Repair: A Combined Systematic Review, Mathematical Model, and Meta-Analysis

## TL;DR

This paper explores how magnetic fields affect neural repair and regeneration using a combination of reviews, models, and meta-analyses.

## Contribution

The study introduces a combined systematic review, mathematical modeling, and meta-analysis approach to assess magnetic field effects on neural repair.

## Key findings

- Higher magnetic field magnitudes enhance neural progenitor cell viability.
- Magnetic field exposure increases NPC proliferation while decreasing astrocytic differentiation.
- The study identifies neural repair processes most responsive to magnetic field exposure.

## Abstract

Magnetic field exposure is a well-established diagnostic tool. However, its use as a therapeutic in regenerative medicine is relatively new. To better understand how magnetic fields affect neural repair in vitro, we started by performing a systematic review of publications that studied neural repair responses to magnetic fields. The 38 included articles were highly heterogeneous, representing 13 cell types, magnetic field magnitudes of 0.0002–10,000 mT with frequencies of 0–150 Hz, and exposure times ranging from one hour to several weeks. Mathematical modeling based on data from the included manuscripts revealed higher magnetic field magnitudes enhance neural progenitor cell (NPC) viability. Finally, for those regenerative processes not influenced by magnitude, frequency, or time, we integrated the data by meta-analyses. Results revealed that magnetic field exposure increases NPC proliferation while decreasing astrocytic differentiation. Collectively, our approach identified neural repair processes that may be most responsive to magnetic field exposure.