This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer’s and Parkinson’s diseases
Abstract
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Taxonomy
TopicsAlzheimer's disease research and treatments · Parkinson's Disease Mechanisms and Treatments · Nuclear Receptors and Signaling
The PLOS One Editors retract this article [1] following concerns about the reliability and integrity of the results reported in Figs 1 and 5. Specifically,
The corresponding author provided data underlying the image results presented in Figs 1, 5, and 6. These did not resolve the concerns raised with the Fig 1A Aβ (6E10) panel and the Fig 1D α-syn panel. In addition, discrepancies observed between the published Fig 5A and the underlying data provided for this figure raised further concerns about the integrity of the published Fig 5A, which call into question the article’s findings that solubilized Aβ and Aggregated Aβ induces aggregation of α-syn into the formation of stable dimers and trimers.
The following additional issues were resolved upon follow-up:
IFT, BS, and EM did not agree with the retraction. BS stands by the published results. LC, PD, GMS, YS, HM, ER, MT, OP, and JXJY either did not respond directly or could not be reached.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, et al. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer’s and Parkinson’s diseases. P Lo S ONE. 2008;3(9): e 3135. doi: 10.1371/journal.pone.0003135 18769546 PMC 2519786 · doi ↗ · pubmed ↗
- 2Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, et al. Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via m Glu R 5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014;9: 18. doi: 10.1186/1750-1326-9-18 24885390 PMC 4041038 · doi ↗ · pubmed ↗