# Total arch replacement for resection of a dedifferentiated liposarcoma of anterior mediastinal origin invading the aorta, left common carotid artery, and left subclavian artery: a case report

**Authors:** Hiroya Matabe, Takuya Nagashima, Yasuhiro Koga, Masuda Haruhiko, Ryo Izubuchi, Shota Yasuda, Keiji Uchida, Tetsukan Woo, Aya Saito

PMC · DOI: 10.1186/s44215-025-00191-9 · General Thoracic and Cardiovascular Surgery Cases · 2025-03-17

## TL;DR

A rare case of a mediastinal dedifferentiated liposarcoma invading major arteries was successfully treated with total arch replacement surgery.

## Contribution

This case report presents a successful surgical approach for a rare and complex dedifferentiated liposarcoma involving multiple arteries.

## Key findings

- Total arch replacement allowed complete resection of a dedifferentiated liposarcoma involving the aortic arch and adjacent arteries.
- The patient had an uneventful postoperative recovery and remains recurrence-free during follow-up.
- Careful surgical planning is crucial for successful outcomes in such complex sarcoma cases.

## Abstract

Dedifferentiated liposarcomas of mediastinal origin are rare. They are prone to local recurrence and distant metastases; therefore, complete surgical resection is desirable and the most important prognostic factor. In this report, we describe a case of dedifferentiated liposarcoma involving the aortic arch, left common carotid artery, and left subclavian artery that was successfully resected via total arch replacement.

A 78-year-old man presenting with hoarseness was diagnosed with a mediastinal tumor. After the examination, the tumor was suspected to be malignant, and the patient was referred to our hospital for surgery. We elected to remove the tumor using an artificial vessel replacement in the aortic arch. The surgery was performed, and the patient’s postoperative course was uneventful. The patient was discharged 26 days postoperatively. He is currently being followed up on an outpatient basis, with no signs of recurrence.

We encountered a case of dedifferentiated liposarcoma involving the aortic arch, left common carotid artery, and left subclavian artery. Careful planning of the surgical procedures and complete resection of the tumor are important for successful outcomes in such cases.

## Linked entities

- **Diseases:** dedifferentiated liposarcoma (MONDO:0020563)

## Full-text entities

- **Diseases:** mediastinal tumor (MESH:D008479), tumor (MESH:D009369), metastases (MESH:D009362), hoarseness (MESH:D006685), Dedifferentiated liposarcomas (MESH:D008080)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC11917125