# Magnetic N-doped CNT stabilized Cu2O as a catalyst for N-arylation of nitriles and aryl halides in a biocompatible deep eutectic solvent

## TL;DR

Researchers developed a magnetic catalyst to efficiently convert nitriles into amides and then into N-aryl amides using a biocompatible solvent.

## Contribution

A novel magnetic N-doped CNT-supported Cu2O catalyst for sequential nitrile hydrolysis and N-arylation in a deep eutectic solvent.

## Key findings

- The catalyst effectively hydrolyzed nitriles into amides with high yields.
- It also facilitated coupling reactions between aryl halides and amides to form N-aryl amides.
- The catalyst can be easily recovered using an external magnetic field.

## Abstract

This study documented the hydrolysis of nitriles by copper(i) oxide immobilized on nitrogen-doped carbon nanotubes (N-CNT/Fe3O4–Cu2O) to yield corresponding amides in the presence of a deep eutectic solvent (ChOH/Gly). Furthermore, the aforementioned catalyst can facilitate the coupling reaction between aryl halides and amides derived by nitrile hydrolysis. Consequently, the integration of two copper-catalyzed processes can efficiently provide N-aryl amides. Choline hydroxide in a deep eutectic solvent serves as a cost-effective organic catalyst in nitrie hydrolysis by forming hydrogen bonds with nitrile, thereby activating it. The catalyst generated higher to satisfactory product yields. One of the special benefits of the catalyst is that it can be restored through the addition of an external magnetic field.

This study documented the hydrolysis of nitriles by copper(i) oxide immobilized on nitrogen-doped carbon nanotubes (N-CNT/Fe3O4–Cu2O) to yield corresponding amides in the presence of a deep eutectic solvent (ChOH/Gly).