# Factors contributing to variability in neurocognitive performance before glioma neurosurgery

## TL;DR

This study explores factors affecting cognitive performance in brain tumor patients before surgery, finding that tumor type, depression, and estimated IQ are key predictors.

## Contribution

The study identifies novel predictors of pretreatment cognitive performance in glioma patients beyond tumor burden.

## Key findings

- Estimated premorbid IQ, tumor volume, astrocytoma diagnosis, depression, and perceived cognitive scores predict objective performance.
- Objective and subjective reports of cognitive impairment showed no association.
- Over 41.7% of cognitive performance variance remains unexplained, suggesting other clinical factors are involved.

## Abstract

Cognitive impairment following anti-tumor treatment is a common concern for brain tumor patients. However, growing evidence indicates that significant impairments can be present even before treatment. The purpose of this study was to identify factors that explain variability in pretreatment test performance, beyond that of tumor burden.

Using multi-step linear regression, we retrospectively probed the contribution of clinical-, tumor-, patient-, and self-reported factors to variance in performance among 96 treatment-naïve brain tumor patients across 13 objective neurocognitive tests. Agreement between subjective and objective reports of cognitive impairment was also examined.

Clinically significant preoperative impairments were observed in both objective and subjective domains. Estimated premorbid intelligence quotient (IQ), tumor volume, diagnosis of an astrocytoma, self-reported depression, and perceived cognitive functioning scores were the most common predictors of objective neurocognitive performance prior to treatment, explaining 12.3%–58.3% of the variance. No association was identified between objective and subjective reports of cognitive impairment.

Glioma patients frequently exhibit objective and subjective impairments prior to treatment. Both tumor- and self-reported factors were identified as predictors of performance, after correcting for estimated premorbid IQ. Nevertheless, more than 41.7% of the variance in cognitive performance remained unexplained, indicating a substantial role for additional, as yet unaccounted for, clinical factors. Notable disparity between objective and subjective cognitive impairment status re-emphasizes the importance of assessing both domains to ascertain a patient’s overall functioning in the context of treatment outcomes.