# Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins

## TL;DR

This study shows that platelets can influence cancer cells, changing their behavior and potentially aiding cancer spread.

## Contribution

The paper reveals that platelets can educate cancer cells, altering gene expression related to inflammation and metastasis.

## Key findings

- Platelets induce transcriptional changes in cancer cells related to glycosylation, inflammation, and metastasis.
- This platelet education directly impacts the cancer cell phenotype.
- The findings suggest new therapeutic strategies targeting platelet-mediated cancer progression.

## Abstract

Cancer-associated thrombosis, a major cause of mortality in cancer patients, exhibits a 4 to 7 times higher incidence compared to the general population. Platelet activation by tumor cells contributes to this pro-thrombotic state. Cancer cell-educated platelets have also been described to be implicated in promoting metastasis. Intriguingly, our team, among others, unveils a reverse process, wherein platelets educate cancer cells by transferring lipids, RNAs, and proteins. Here, focusing on colorectal and pancreatic cancers, our study investigates genes and proteins mediating platelet education of cancer cells. We demonstrated, for the first time, that platelets can educate cancer cells by inducing changes in the transcription of genes related to glycosylation, inflammation, and metastasis in cancer cells themselves. These results indicate a direct impact of platelets on cancer cell phenotype. This novel insight suggests potential therapeutic avenues for cancer treatment, disrupting platelet-mediated alterations and influencing the course of cancer progression.