Correlation of risk factors for ischemic stroke with uric acid/creatinine ratio and cerebral vascular hemodynamic index (CVHI) in physical examination population

TL;DR

This study explores how uric acid/creatinine ratio and cerebral vascular hemodynamic index relate to stroke risk factors in a physical examination population.

Contribution

The study identifies a negative correlation between uric acid/creatinine ratio and cerebral vascular hemodynamic index in stroke risk assessment.

Findings

High uric acid/creatinine ratio is associated with higher prevalence of hypertension, diabetes, and hyperlipidemia.

Advanced age, smoking, and obesity are significant risk factors for ischemic stroke.

The SUA/Cr ratio is negatively correlated with the CVHI score.

Abstract

To investigate the risk of ischemic stroke, uric acid/creatinine ratio, cerebral vascular hemodynamic index (CVHI) and risk factors of stroke in physical examination population.

This was a retrospective study. Four hundred cases undergoing physical examination at physical examination center in Baoding No.1 Central Hospital from January 2023 to December 2023 were selected as subjects, and their general data were collected. They were divided into low ratio group, medium ratio group and high ratio group depending on the uric acid/creatinine ratio, and were classified as high-risk group, medium-risk group and low-risk group as per CVHI, the general data of all subjects were compared and analyzed.

Multifactorial Logistic regression analysis was performed after assignment of stroke risk factors as dependent variables yielding that advanced age, smoking, alcohol abuse, hypertension, diabetes mellitus, BMI, hyperlipidemia, and hyperuricemia were risk factors for ischemic stroke(P<0.05). Those with high uric acid/creatinine ratio were markedly higher than those with medium and low ratio in the proportion of alcohol abuse, hypertension, diabetes mellitus, and hyperlipidemia, with statistically significant differences (P<0.05). Obesity, advanced age, smoking, hypertension, diabetes mellitus, and hyperlipidemia were obviously higher in the high-risk group for stroke than in the medium- and low-risk groups, with statistically significant differences (P<0.05).

Risk factors for ischemic stroke predispose to older age groups, and are linked to underlying medical conditions, especially in those with high uric acid/creatinine ratios and those at high risk of stroke. The SUA/Cr ratio is negatively correlated with the CVHI score.