Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

TL;DR

This paper reviews gastrodin's potential in treating neurological diseases by exploring its effects on ferroptosis and pyroptosis.

Contribution

The paper provides new insights into gastrodin's mechanisms in regulating ferroptosis and pyroptosis for neurological diseases.

Findings

Gastrodin shows anti-inflammatory, antioxidant, and antiapoptotic effects.

It may help treat cognitive decline and reperfusion injuries through antiferroptosis and antipyroptosis.

Gastrodin is a potential drug for neurological and ischemic diseases.

Abstract

Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory, antioxidant, antiapoptosis, and other aspects. As the global aging process continues to intensify, diseases of the central nervous system, cardiovascular system, and immune system have brought serious economic and mental burdens to families and have become a major challenge for global public health resources. Many studies have proved that gastrodin may be a potential drug for neurological diseases and ischemic injury but its mechanism of action is still unclear. [Correction added on 19 February 2025, after first online publication: In the preceding sentence, “the treatment of various systemic diseases” has been corrected to “neurological diseases and ischemic injury” in this version.]. In this study, the pharmacological action of gastrodin and the possible mechanism of regulating ferroptosis and pyroptosis were reviewed to provide a new treatment and research direction for clinicians and researchers.

Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis.

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