# Indications and Outcomes of Nerve Reconstructions After Resection of Extremity Tumors: A Systematic Review

## TL;DR

This review shows that nerve reconstruction after tumor removal in limbs can help restore motor and sensory function and reduce chronic pain.

## Contribution

The study provides a systematic overview of the outcomes and indications for nerve reconstruction following extremity tumor resection.

## Key findings

- Most patients showed improved motor and sensory function after nerve reconstruction.
- Over 77% of patients achieved functional recovery of ≥3 on the MRC scale.
- More than 80% of patients recovered to a protective sensation level of S2 or higher.

## Abstract

Objective: Peripheral nerve injuries resulting from tumor resection are unusual, but occasionally unavoidable. It can result in serious morbidity in motor deficits, sensory deficits, and even chronic pain. Nerve reconstruction after tumor resection is possible and seems to have positive recovery outcomes. However, nerve reconstructions are rarely performed and clear outcomes of nerve reconstructions after tumor resection are missing. This review aims to create an overview of the indications and outcomes in these patients. Methods: A systematic review was performed in May 2024 in PubMed and Embase databases according to the PRISMA guidelines. Search terms related to “tumor” and “nerve reconstruction” were used. Studies evaluating nerve reconstructions (nerve graft, transfer or coaptation) after tumor resection were included. Tumors not located in the extremities were excluded. A qualitative synthesis was performed on all studies. Where possible, motor, and sensory grades were recalculated according to the Medical Research Council (MRC)-scale. Results: Fifty-nine articles were included for quality synthesis after full-text screening. A total of 90 patients were described of which 44 after resection of malignant tumors. Most patients improved in motor and sensory function after nerve reconstruction. In both benign and malignant tumors, 77% demonstrated functional recovery on the MRC scale of ≥3. Most of the patients, >80%, recovered to a protective sensation of S2 or higher. Conclusion: Nerve reconstruction after tumor resection can help recover both sensory and motor function and may avoid chronic nerve pain. Nerve reconstructions should therefore be considered in tumor surgery.