# Case Report: Multiple mesenchymal hamartomas showing spontaneous motility in the nasopharynx

## TL;DR

A 58-year-old man had multiple rare mesenchymal hamartomas in his nasopharynx that showed unusual spontaneous movement.

## Contribution

This case report presents a rare instance of multiple mesenchymal hamartomas with spontaneous motility in the nasopharynx.

## Key findings

- The tumors exhibited repeating contraction and relaxation during endoscopy.
- Histological analysis confirmed the tumors as mesenchymal hamartomas.
- Spontaneous motility was linked to the presence of muscle tissue and ganglion cells.

## Abstract

Hamartomas are classified as either epithelial, mesenchymal, or epithelium-mesenchymal mixed types. They occur extremely rarely in the nasopharynx. A 58-year-old man had multiple tumors with repeating contraction and relaxation in the nasopharynx shown on endoscopy. One of the tumors was endoscopically resected under general anesthesia for histological examination and was finally diagnosed as mesenchymal hamartoma. Smooth muscle tissue is sometimes confirmed in mesenchymal hamartomas, but spontaneous contraction in nasopharyngeal hamartomas is rare. In this case, coexistence of muscle tissue, Cajal interstitial cell-like cells, and ganglion cells was thought to be a mechanism of spontaneous motility of the tumors. Aberrant or residual foregut tissue in the nasopharynx due to embryological factors may be a contributing factor to the multiple occurrences.