# A multidisciplinary protocol for reducing excessive and maintaining a healthy body weight in the personalized management of chronic diseases in children and adults

## TL;DR

This paper introduces a personalized weight management program to improve asthma control and quality of life in children and adults with chronic diseases.

## Contribution

A multidisciplinary, precision medicine-based protocol for weight management tailored to asthma phenotypes.

## Key findings

- The program includes meal replacement, dietary plans, counseling, and physical activity tailored to individual disease phenotypes.
- It aims to improve asthma control and reduce symptom frequency and severity through personalized interventions.
- The study expects to enhance overall quality of life by addressing underlying pathophysiological mechanisms.

## Abstract

Despite regularly used treatment asthma in both children and adults is not fully controlled. This is more prominent in certain disease subtypes, such as obese asthma. The vast complexity of asthma phenotypes and often overlapping endotypes emphasizes the need for implementing the concept of precision medicine in disease management. In order to address these concerns, an innovative and personalized programme for reducing excessive and maintaining a healthy body weight will be developed by experts from pharmaceutical and food industry (Belupo Inc. and Podravka Inc., Croatia) as well as clinical experts (Srebrnjak Children`s Hospital, Croatia). The programme will involve meals replacement (standard and innovative formulas), dietary program and nutritional counseling, physical activity and other individually tailored measures according specific disease phenotypes and underlying pathophysiological mechanisms in each participant. The outcomes of this study should contribute to better control of the underlying condition, reduction of the frequency and severity of symptoms and, consequently, in the improvement of the participant’s overall quality of life.