# Research progress on molecular mechanism of liver metastasis of gastric cancer and treatment with traditional Chinese medicine

## TL;DR

This paper reviews how gastric cancer spreads to the liver and how traditional Chinese medicine may help treat it.

## Contribution

The paper summarizes recent advances in understanding the mechanisms of gastric cancer liver metastasis and the role of traditional Chinese medicine in its treatment.

## Key findings

- Gastric cancer liver metastasis involves multiple targets and complex mechanisms.
- Traditional Chinese medicine shows potential in inhibiting gastric cancer growth and metastasis.
- Recent studies have made progress in understanding how TCM interventions affect liver metastasis.

## Abstract

Gastric cancer liver metastasis (GCLM) refers to the process of cancer cells from the stomach spreading to the liver, which is an important sign of the deterioration of gastric cancer (GC) and has a profound influence on the treatment and prognosis of patients. Once GC has liver metastasis, the treatment becomes more complex and challenging, which seriously affects the survival rate of patients with GC. Therefore, studying the mechanism and treatment of GCLM is extremely necessary. At present, the continuous research on GCLM has revealed that the mechanism of its occurrence and development involves the comprehensive effect of multiple targets and links. Traditional Chinese medicine (TCM) has the advantages of wide sources, excellent efficacy, and small toxicity and side effects, which have become the focus of current antitumor research. TCM, Chinese medicine monomers, or TCM compounds can inhibit the growth and metastasis of GC. In recent years, Chinese medicine has made substantial achievements in experimental research on the intervention of GCLM. This article reviews the progress of its intervention mechanism.