# Transcription Regulatory Protein SIN3 (YOL004W) Influences Mutation Rates in Saccharomyces cerevisiae

## TL;DR

This study shows that the SIN3 protein in yeast affects mutation rates, indicating a role in genome stability.

## Contribution

The paper reveals a new role for SIN3 in influencing mutation rates in the CAN1 gene.

## Key findings

- SIN3 affects mutation rates in the CAN1 reporter gene.
- This suggests SIN3 has an impact on genome stability in yeast.

## Abstract

SIN3
(YOL004W) codes for a protein in
Saccharomyces cerevisiae
which is suggested to function as a broad cellular transcription regulator through the binding of histone deacetylases and other enzymes to form a large protein complex that modifies chromatin. In addition,
SIN3
has also demonstrated potential roles in epigenetic silencing, DNA methylation, and centromere function. Here we report a new role of
SIN3
in affecting mutation rates within the
CAN1
reporter gene, suggesting an impact on genome stability.