# Superior vena cava syndrome due to hyper-homo-cysteinemia: A rare case report

## TL;DR

This case report describes a rare instance of superior vena cava syndrome caused by high homocysteine levels, not by cancer or blood clots.

## Contribution

The paper highlights hyper-homo-cysteinemia as a rare but important cause of superior vena cava syndrome.

## Key findings

- Superior vena cava syndrome can occur due to hyper-homo-cysteinemia.
- This case is rare and not typically linked to cancer or catheter-related thrombosis.

## Abstract

Superior vena cava (SVC) syndrome (SYN) is a relatively frequent complication observed in patients with malignancies and is frequently
characterized as a medical emergency. In most instances, it arises from mechanical obstruction of the SVC caused by extraluminal
compression from primary intrathoracic malignancies. Intraluminal obstruction (OB) resulting from thrombosis (TMBO) may also lead to the
manifestation of symptoms and signs associated with the syndrome. Clot-related SVC OB is primarily linked to the presence of indwelling
central venous catheters and pacemaker leads. However, data shows that this is due to hyper-homo-cysteinemia (HY-HM-CT).