# Non-medicinal oral contrast in upper abdominal MRI for MR-guided radiotherapy: A scoping review

## TL;DR

This review explores non-medicinal oral contrast agents for upper abdominal MRI to improve safety in MR-guided radiotherapy by better visualizing organs at risk.

## Contribution

The study maps existing non-medicinal oral contrast agents for upper abdominal MRI and identifies gaps in their use for MR-guided radiotherapy.

## Key findings

- 31 distinct non-medicinal oral contrast agents were identified, mainly used for tissue visualization in diagnostic MRI.
- No studies have examined these agents in MR-guided radiotherapy planning or delivery.
- Most research is quantitative, with limited focus on patient experience or qualitative methods.

## Abstract

Using non-medicinal oral contrast agents may aid safe delivery of magnetic resonance image-guided (MR-guided) radiotherapy by improving the ability to visualise and avoid excessive radiation dose to adjacent bowel/stomach. This scoping review aims to map the literature on non-medicinal oral contrasts used in upper-abdominal diagnostic or therapeutic magnetic resonance imaging (MRI) to find potential candidates for employing in MR-guided radiotherapy and identify gaps in knowledge for further study.

A scoping review of non-medicinal oral contrast used in upper-abdominal MRI research followed a pre-defined protocol based on Arksey and O’Malley’s framework. Data were charted and reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Scoping Reviews reporting guidelines.

Forty-seven studies from 1955 screened abstracts were charted. Thirty-one distinct non-medicinal oral contrast were identified, used primarily to enhance tissue visualisation (89 %) or observe motility (11 %) in diagnostic studies. All studies reported to be predominantly quantitative; only 13 % included participant experience via questionnaires and none used qualitative methods. No studies have examined the efficacy of non-medicinal oral contrasts in MR-guided radiotherapy planning or delivery.

Non-medicinal oral contrasts have been extensively investigated in diagnostic MRI to enhance gastrointestinal visualisation and assess motility. However, non-medicinal oral contrasts have not been investigated in the context of radiotherapy planning and treatment. Qualitative evaluation of the patient experience of non-medicinal oral contrasts in magnetic resonance image-guided radiotherapy should be considered alongside studies quantifying the potential clinical benefit.

This review summarises the properties of non-medicinal oral contrasts and identifies critical gaps in the current evidence, particularly the absence of qualitative research in this domain and the unexplored potential for their application in MR-guided radiotherapy planning and delivery.