# Machine learning-driven ultrasound radiomics for assessing axillary lymph node burden in breast cancer

## TL;DR

This study uses ultrasound imaging and machine learning to better predict lymph node involvement in breast cancer patients.

## Contribution

A novel combined clinical-radiomics model is proposed for predicting axillary lymph node burden in breast cancer.

## Key findings

- The combined logistic regression model achieved an AUC of 0.857 in training and 0.820 in validation.
- The model balanced sensitivity and specificity at a 52% cutoff value.
- A nomogram was developed to assist clinicians in risk assessment.

## Abstract

This study explores the value of combining intratumoral and peritumoral radiomics features from ultrasound imaging with clinical characteristics to assess axillary lymph node burden in breast cancer patients.

A total of 131 breast cancer patients with axillary lymph node metastasis (ALNM) were enrolled between June 2019 and September 2024. Patients were divided into low (n=79) and high (n=52) axillary lymph node burden (ALNB) groups. They were further split into training (n=92) and validation (n=39) cohorts. Intratumoral and peritumoral features were analyzed using the maximum relevance minimum redundancy (MRMR) and least absolute shrinkage and selection operator (LASSO) methods. Six machine learning models were evaluated, and a combined clinical-radiomics model was built.

The combined logistic regression model exhibited superior diagnostic performance for high axillary lymph node burden, with areas under the ROC curve (AUC) of 0.857 in the training cohort and 0.820 in the validation cohort, outperforming individual models. The model balanced sensitivity and specificity well at a 52% cutoff value. A nomogram provided a practical risk assessment tool for clinicians.

The combined clinical-radiomics model showed excellent predictive ability and may aid in optimizing management and treatment decisions for breast cancer patients.