# Post-COVID-19 Inflammatory Arthritis Treated With Upadacitinib: A Case Report

**Authors:** Cherie S Zhi, Ami Ben-Artzi

PMC · DOI: 10.7759/cureus.78799 · 2025-02-09

## TL;DR

This case report shows that upadacitinib effectively treats inflammatory arthritis that occurs after a COVID-19 infection.

## Contribution

The report demonstrates the clinical effectiveness of upadacitinib in treating post-COVID-19 inflammatory arthritis.

## Key findings

- Two patients with post-COVID-19 inflammatory arthritis showed meaningful clinical improvement with upadacitinib.
- Upadacitinib was associated with reduced inflammation markers and symptom relief in treated patients.

## Abstract

Two patients who developed inflammatory arthritis following COVID-19 infection are presented, characterized by arthralgias, arthritis, and elevated markers of inflammation (C-reactive protein). Both patients had clinically meaningful responses to treatment with upadacitinib, a Janus Kinase inhibitor (JAKi). This case report highlights the efficacy and safety of upadacitinib in the treatment of post-COVID-19 inflammatory arthritis.

## Linked entities

- **Chemicals:** upadacitinib (PubChem CID 58557659)
- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** COVID-19 infection (MESH:D000086382), arthralgias (MESH:D018771), Post-COVID-19 (MESH:D000094024), inflammation (MESH:D007249), Inflammatory Arthritis (MESH:D001168)
- **Chemicals:** Upadacitinib (MESH:C000613732)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC11902908