# Diastolic Dysfunction Unveiling Cardiac Light-Chain Amyloidosis: A Case Report

## TL;DR

A case report highlights how diastolic dysfunction can indicate cardiac light-chain amyloidosis, emphasizing the importance of early diagnosis for better outcomes.

## Contribution

The case illustrates the diagnostic value of diastolic dysfunction in identifying cardiac light-chain amyloidosis.

## Key findings

- The patient showed concentric left ventricular hypertrophy and restrictive filling pattern on echocardiography.
- Cardiac MRI, nuclear imaging, and biopsy confirmed cardiac light-chain amyloidosis.
- Early diagnosis allows for timely treatment, potentially halting disease progression.

## Abstract

Cardiac light-chain amyloidosis represents a critical component of this multi-systemic disease, significantly impacting prognosis. The extent of cardiac free light-chain deposition is the primary determinant of survival.

We report the case of a 67-year-old male with a 10-year history of diabetes mellitus and arterial hypertension who presented with a two-day history of chest discomfort and difficulty lying down or sleeping, along with a two-month history of progressively worsening exertional dyspnea. On examination, the patient exhibited low blood pressure. A 12-lead electrocardiogram revealed poor R-wave progression and left ventricular hypertrophy. Further evaluation using 2D echocardiography demonstrated significant concentric left ventricular hypertrophy, a restrictive filling pattern, and mild pericardial effusion. Cardiac magnetic resonance imaging, nuclear imaging, and biopsy confirmed the diagnosis of cardiac light-chain amyloidosis.

Timely recognition and a high index of suspicion are essential for the early diagnosis of cardiac amyloidosis. Prompt diagnosis enables the initiation of definitive therapy, which may halt disease progression and significantly improve prognosis.