# Multiparametric Outcome Assessment After Transcatheter Aortic Valve Implantation—A Systematic Review

## TL;DR

This systematic review summarizes factors influencing outcomes in patients with aortic stenosis undergoing transcatheter aortic valve implantation.

## Contribution

The study compiles and analyzes factors affecting TAVI outcomes, highlighting areas needing further research for better predictive tools.

## Key findings

- Psychosocial, socioeconomic, and clinical factors are associated with TAVI outcomes.
- Valve parameters, comorbidities, and treatment methods influence patient outcomes.
- Conflicting results exist regarding the impact of right ventricular dysfunction and paravalvular leaks on mortality.

## Abstract

Backround/Objectives: Aortic stenosis (AS) is the most commonly acquired valvular disorder. Patient risk stratification and the development of an accurate and reliable tool are crucial in identifying suitable candidates for TAVI. The present review summarized the current state of knowledge on the influence of selected factors on the outcomes and course of patients with AS undergoing transcatheter aortic valve implantation (TAVI). Methods: The inclusion criteria for the present systematic review were as follows: (1) studies indexed in the medical databases PubMed, MEDLINE, EMBASE, CINAHL, Web of Science, and Scopus; (2) full-text articles available in English; (3) papers published between 2013 and 2023; and (4) addressing the topic of assessing the impact of factors on the outcomes of patients with aortic stenosis undergoing TAVI. This review used PRISMA 2020 reporting guidelines for systematic reviews and meta-analyses. Results: One hundred and thirty-two studies were eligible for this review. The available studies showed an association of psychosocial and socioeconomic factors, valve parameters, comorbidities, clinical factors, treatment-related factors, biomarkers, and treatment methods with the outcomes of patients with AS undergoing TAVI. Conclusions: Given the conflicting results obtained regarding the impact of right ventricular dysfunction, paravalvular leaks, and treatment method on the mortality of patients undergoing aortic valve implantation, further research in these areas is needed. In view of the researchers’ differing views on some of the factors affecting patient outcomes after TAVI, further analysis is needed to develop a new tool for assessing predictive outcomes in AS patients. This study is registered at PROSPERO (CRD42024612752).