Influence of FOXP3 rs2280883 and rs3761548 Variants on IL-10 and TGF-β1 Serum Levels and Plaque Psoriasis Risk in the Mexican Population

TL;DR

This study explores how genetic variants in the FOXP3 gene affect immune responses and psoriasis risk in the Mexican population.

Contribution

The study identifies a specific FOXP3 variant linked to increased psoriasis risk and highlights IL-10's role independent of Treg function.

Findings

The FOXP3 rs2280883 variant is associated with increased plaque psoriasis risk in the Mexican population.

Elevated IL-10 levels in psoriasis patients suggest immune dysregulation beyond FOXP3-mediated Treg function.

No significant association was found between rs3761548 and TGF-β1 levels with psoriasis risk.

Abstract

Plaque psoriasis (PP) is a chronic immune-mediated skin disorder with a genetic basis, characterized by abnormal T-cell responses. This study investigated the role of FOXP3 gene variants rs2280883 and rs3761548 in T-cell regulation through their effects on IL-10 and TGF-β1 cytokine levels and their association with PP risk. A case-control study was conducted, including 101 individuals with PP and 106 healthy controls from the Mexican population. Genotyping of FOXP3 variants was performed using PCR-RFLP, and cytokine levels were measured with ELISA kits. Significant differences in allele and genotype frequencies of the rs2280883 variant were observed between PP patients and controls, suggesting an association with an increased risk of PP. IL-10 levels were found to be elevated in PP patients, regardless of FOXP3 gene variants, indicating that cytokine dysregulation in PP may involve alternative pathways independent of FOXP3-mediated regulatory T-cell (Treg) function. No significant differences were detected in TGF-β1 levels or rs3761548 genotype frequencies across the study groups. In conclusion, the rs2280883 variant in the FOXP3 gene is significantly associated with a higher risk of developing PP in the Mexican population, while dysregulated IL-10 levels suggest a complex cytokine interaction beyond Treg activity.

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