# Overlooked Carbamazepine Toxicity: A Diagnostic Pitfall in an Elderly Patient With Dizziness

**Authors:** Koki Kobayashi, Ayano Hamai, Takayuki Ando

PMC · DOI: 10.7759/cureus.78802 · 2025-02-10

## TL;DR

An elderly patient's dizziness was initially misdiagnosed as a balance issue but was later found to be caused by a drug toxicity.

## Contribution

This case highlights the diagnostic challenge of mistaking carbamazepine toxicity for peripheral vertigo in elderly patients.

## Key findings

- A 79-year-old man was misdiagnosed with peripheral vertigo before being found to have carbamazepine toxicity.
- The case emphasizes the importance of monitoring carbamazepine levels and reviewing medications in elderly patients.
- Carbamazepine toxicity can mimic central vertigo and lead to altered consciousness and involuntary movements.

## Abstract

Dizziness is a common chief complaint that often poses a diagnostic challenge. A 79-year-old man was initially misdiagnosed with peripheral vertigo based on normal neuroimaging but later developed altered consciousness and involuntary limb movements, ultimately revealing carbamazepine (CBZ) toxicity. This case highlights a critical diagnostic pitfall: prematurely attributing dizziness to peripheral vertigo without considering drug-induced syndromes. Although the potential role of concomitant amiodarone use remains uncertain, this case also underscores the importance of cautious CBZ dose escalation, serum level monitoring, and a thorough medication review. Recognizing CBZ toxicity as a mimicker of central vertigo is crucial for ensuring timely and accurate diagnosis, especially in elderly patients.

## Linked entities

- **Chemicals:** carbamazepine (PubChem CID 2554), amiodarone (PubChem CID 2157)
- **Diseases:** peripheral vertigo (MONDO:0004900)

## Full-text entities

- **Diseases:** involuntary limb movements (MESH:D001259), Toxicity (MESH:D064420), peripheral vertigo (MESH:D014717), Dizziness (MESH:D004244), altered consciousness (MESH:D003244)
- **Chemicals:** CBZ (MESH:D002220), amiodarone (MESH:D000638)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11897834/full.md

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Source: https://tomesphere.com/paper/PMC11897834