# The impact of a virtual wound on pain sensitivity: insights into the affective dimension of pain

## TL;DR

This study explores how a virtual wound in VR affects how people perceive pain, showing that it makes pain feel more intense.

## Contribution

The study introduces a novel VR-based method to assess the affective dimension of pain in healthy individuals.

## Key findings

- Participants had lower pain detection thresholds and reported increased pain intensity in the VR-wound condition.
- The effect of the virtual wound on pain perception was more pronounced during the second study visit.
- VR can enhance the perception of pain, offering insights into its affective component.

## Abstract

The perception of pain is difficult to assess due to the complex combination of various components related to nociception, experience, and cognition. There are currently no biomarkers to assess the affective component of pain in healthy volunteers. Using Virtual Reality (VR), it may be possible to assess changes in pain perception when adding an affective component to painful stimulation.

In this two-visit feasibility study, we assess the effect of a simulated wound in VR on the electrical pain detection (PDT) and tolerance (PTT) threshold in 24 healthy male study participants. The VR simulation presented a copy of the research room from first person view. Prior to each VR assessment, study participants were primed by interacting with the VR environment. Two conditions were assessed: (1) VR-Wound: a burn-wound, smoke, and electrical sparks become visible and audible with increasing stimulus intensity, and (2) VR-neutral: no additional aspects. The PDT and PTT to electrical stimuli were recorded during both VR conditions and outside of VR. VAS-Questionnaires were used to assess unpleasantness and fear.

The PDT decreased when a virtual wound is presented compared to a neutral condition. Study participants experienced the electrical stimulation as more painful and more intense during the wound simulation than during the neutral condition. The effect was more pronounced during the second visit.

VR enhanced the perception of pain, thereby providing new insights into the affective component of pain. Further testing of this methodology is warranted by performing a clinical study that evaluates drug effects on the affective component of pain.