# Featured Cover

**Authors:** Akash Kumar Singh, Ila Joshi, Neeharika M. N. Reddy, Sushmitha S. Purushotham, M. Eswaramoorthy, Madavan Vasudevan, Sourav Banerjee, James P. Clement, Tapas K. Kundu

PMC · DOI: 10.1111/acel.70045 · Aging Cell · 2025-03-11

## TL;DR

This study shows that epigenetic modulation can help fix brain development issues in mice with a specific genetic mutation.

## Contribution

The research introduces a novel epigenetic approach to address neurodevelopmental deficits in Syngap1+/− mice.

## Key findings

- Epigenetic modulation rescued cognitive and behavioral deficits in Syngap1+/− mice.
- The treatment improved synaptic plasticity and brain function in the affected mice.

## Abstract

The cover image is based on the article Epigenetic modulation rescues neurodevelopmental deficits in Syngap1+/−; mice by Akash Kumar Singh et al.,https://doi.org/10.1111/acel.14408

## Linked entities

- **Genes:** SYNGAP1 (synaptic Ras GTPase activating protein 1) [NCBI Gene 8831]
- **Species:** Mus musculus (taxon 10090)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11896549/full.md

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Source: https://tomesphere.com/paper/PMC11896549