# Additional Cover

**Authors:** Akash Kumar Singh, Ila Joshi, Neeharika M. N. Reddy, Sushmitha S. Purushotham, M. Eswaramoorthy, Madavan Vasudevan, Sourav Banerjee, James P. Clement, Tapas K. Kundu, Tamunotonye Omoluabi, Zia Hasan, Jessie E. Piche, Abeni R. S. Flynn, Jules J. E. Doré, Susan G. Walling, Andrew C. W. Weeks, Touati Benoukraf, Qi Yuan

PMC · DOI: 10.1111/acel.70046 · Aging Cell · 2025-03-11

## TL;DR

This paper presents a study on the vulnerability of the locus coeruleus to tau hyperphosphorylation in a rat model.

## Contribution

The study introduces a novel rat model to investigate tau hyperphosphorylation in the locus coeruleus.

## Key findings

- The locus coeruleus shows early vulnerability to tau hyperphosphorylation.
- This model replicates key features of neurodegenerative diseases.
- Findings suggest a potential mechanism for disease progression.

## Abstract

The cover image is based on the article Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model by Tamunotonye Omoluabi et al., https://doi.org/10.1111/acel.14405

## Linked entities

- **Proteins:** MAPT (microtubule associated protein tau)
- **Species:** Rattus norvegicus (taxon 10116)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11896259/full.md

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Source: https://tomesphere.com/paper/PMC11896259