# Complete genome sequences of Yersinia pestis 6/69 strain isolated from a bubonic plague patient in Madagascar and its isogenic strain cured of pPCP1

**Authors:** Emelyne Bougit, Guillem Mas Fiol, Pierre Lê-Bury, Charlotte Balière, Valérie Caro, Javier Pizarro-Cerdá, Olivier Dussurget

PMC · DOI: 10.1128/mra.01021-24 · Microbiology Resource Announcements · 2025-02-20

## TL;DR

This paper presents the complete genome sequences of a bubonic plague-causing Yersinia pestis strain and a modified version without a specific virulence plasmid.

## Contribution

The novel contribution is the sequencing of a clinical Y. pestis isolate and its isogenic derivative lacking the pPCP1 plasmid.

## Key findings

- The genome of Yersinia pestis strain 6/69 was fully sequenced.
- An isogenic strain of 6/69 cured of the pPCP1 plasmid was also sequenced.
- The findings provide resources for studying plague pathogenesis.

## Abstract

We report the complete genome sequences of two valuable strains to investigate plague pathogenesis: (i) Yersinia pestis strain 6/69, which was isolated from a bubonic plague patient in Madagascar and contains pCD1, pMT1, and pPCP1 virulence plasmids, and (ii) the 6/69 strain cured of pPCP1.

## Linked entities

- **Diseases:** bubonic plague (MONDO:0001112)
- **Species:** Yersinia pestis (taxon 632)

## Full-text entities

- **Diseases:** bubonic plague (MESH:D010930)
- **Species:** Homo sapiens (human, species) [taxon 9606], Yersinia pestis (species) [taxon 632]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11895438/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11895438/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11895438/full.md

---
Source: https://tomesphere.com/paper/PMC11895438