# Long-term consumption of green tea protects the mental health of middle-aged and older adult men by improving inflammation levels

**Authors:** Zhenyu Wan, Qirong Wan, Xucong Qin, Gaohua Wang, Hong Lin, Yong Jin, Bing Wan, Linfeng Ai, Juan Wei

PMC · DOI: 10.3389/fpubh.2025.1531953 · Frontiers in Public Health · 2025-02-25

## TL;DR

Drinking green tea long-term may help reduce depression and improve health in older men by lowering inflammation and improving sleep and brain structure.

## Contribution

This study provides empirical evidence that long-term green tea consumption reduces depression and brain aging in older men.

## Key findings

- Tea drinkers had lower BMI, depression, and inflammation compared to the control group.
- Testosterone levels were higher in the tea-drinking group.
- Tea consumption was linked to greater gray matter volume in the right precuneus.

## Abstract

Middle-aged and older adult men are at a heightened risk of depression. Green tea, as a popular beverage, has drawn widespread attention for its health benefits. However, there remains controversy over the effects of green tea on combating depression and regulating hormones.

This study aimed to investigate the effects of long-term green tea consumption on depression levels, hormones, and brain structure in, middle-aged and older adult men.

A total of 280 volunteers participated in the study, divided into a tea-drinking group and a control group. Basic demographic information and biological marker data, as well as MRI data from some of the volunteers, were collected. A controlled study was conducted to explore the effects of long-term tea drinking on them.

BMI (p = 0.002), depression level (p = 0.003), insomnia severity (p = 0.008), and systemic inflammation index (p = 0.009) were significantly lower in the tea drinking group, and their testosterone levels were significantly higher than those in the control group (p = 0.001). Moreover, GM volume in the right precuneus in the control group was significantly reduced compared with that in the tea drinking group.

Long-term tea consumption helps reduce BMI and increase testosterone levels in middle-aged and older adult men, and it can also reduce their risk of depression by lowering inflammation and improving sleep quality. Additionally, long-term tea consumption may have the potential to delay brain aging in middle-aged and older adult men.

## Linked entities

- **Diseases:** depression (MONDO:0002050), insomnia (MONDO:0013600)

## Full-text entities

- **Diseases:** depression (MESH:D003866), insomnia (MESH:D007319), inflammation (MESH:D007249)
- **Chemicals:** testosterone (MESH:D013739)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11893420/full.md

## References

73 references — full list in the complete paper: https://tomesphere.com/paper/PMC11893420/full.md

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Source: https://tomesphere.com/paper/PMC11893420