# Systemic sarcoidosis presenting as acute rapidly progressive proptosis

**Authors:** Maria Valeria da Silva, Yael Chavez, Maria Laura Di Nicola, Jan M. A. Delabie, Kalpana Rose, Hatem Krema

PMC · DOI: 10.5935/0004-2749.20230005 · Arquivos Brasileiros de Oftalmologia · 2022-01-31

## TL;DR

A patient with sudden eye swelling was diagnosed with sarcoidosis, a chronic inflammatory disease, which responded well to corticosteroid treatment.

## Contribution

This case highlights an unusual acute presentation of sarcoidosis as a rapidly progressive orbital mass.

## Key findings

- A biopsy confirmed sarcoidosis as the cause of acute proptosis.
- The patient's symptoms and systemic sarcoidosis resolved with corticosteroid therapy.

## Abstract

Sarcoidosis is a generalized systemic chronic inflammation that rarely involves
the orbit. As a chronic inflammation, sarcoidosis typically manifests with an
insidious onset and slowly progressive course. We report a case of acute-onset
proptosis resulting from a rapidly growing diffuse orbital mass that simulated
malignant growth, which was biopsy proven to be the first manifestation of
systemic sarcoidosis. The patient demonstrated complete resolution of proptosis
and systemic involvement with long-term corticosteroid treatment.

## Linked entities

- **Diseases:** sarcoidosis (MONDO:0008399)

## Full-text entities

- **Diseases:** Sarcoidosis (MESH:D012507), inflammation (MESH:D007249), proptosis (MESH:D005094), orbital mass (MESH:D009916)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11892485/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC11892485/full.md

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Source: https://tomesphere.com/paper/PMC11892485