This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: LKB1 Suppresses Androgen Synthesis in a Mouse Model of Hyperandrogenism via IGF‐1 Signaling
TL;DR
This retracted paper claimed that LKB1 suppresses androgen production in mice through IGF-1 signaling, but data issues invalidated the findings.
Contribution
The study aimed to show a novel mechanism of LKB1 in regulating androgen synthesis via IGF-1 signaling in a mouse model.
Findings
LKB1 was reported to suppress androgen synthesis in a mouse model of hyperandrogenism.
The proposed mechanism involved IGF-1 signaling pathway activation.
The conclusions were found to be compromised due to image duplication issues.
Abstract
RETRACTION: Y. Xu, Y. Gao, Z. Huang, Y. Zheng, W. Teng, D. Zheng, and X. Zheng, “LKB1 Suppresses Androgen Synthesis in a Mouse Model of Hyperandrogenism via IGF‐1 Signaling,” FEBS Open Bio 9, no. 10 (2019): 1817‐1825, https://doi.org/10.1002/2211‐5463.12723. The above article, published online on 12 September 2019, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Miguel A. De la Rosa; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image duplications between this (Figure 1C, 1H) and other articles that were previously published or published in the same or following year. Given the extent of the identified issues, the editors have lost confidence in the data presented and consider the conclusions…
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Taxonomy
TopicsCancer-related molecular mechanisms research · Peroxisome Proliferator-Activated Receptors
RETRACTION: Y. Xu, Y. Gao, Z. Huang, Y. Zheng, W. Teng, D. Zheng, and X. Zheng, “LKB1 Suppresses Androgen Synthesis in a Mouse Model of Hyperandrogenism via IGF‐1 Signaling,” FEBS Open Bio 9, no. 10 (2019): 1817‐1825, https://doi.org/10.1002/2211‐5463.12723.
The above article, published online on 12 September 2019, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Miguel A. De la Rosa; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image duplications between this (Figure 1C, 1H) and other articles that were previously published or published in the same or following year. Given the extent of the identified issues, the editors have lost confidence in the data presented and consider the conclusions of this manuscript substantially compromised.