This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: CDKL5 Promotes Proliferation, Migration, and Chemotherapeutic Drug Resistance of Glioma Cells via Activation of the PI3K/AKT Signaling Pathway
TL;DR
This retracted paper claimed CDKL5 promotes glioma cell growth and drug resistance through the PI3K/AKT pathway.
Contribution
The paper originally proposed a novel mechanism involving CDKL5 and the PI3K/AKT pathway in glioma progression.
Findings
CDKL5 was reported to enhance glioma cell proliferation and migration.
The study suggested CDKL5 contributes to chemotherapeutic drug resistance.
The PI3K/AKT signaling pathway was implicated as the mechanism involved.
Abstract
RETRACTION: Z. Jiang, T. Gong, and H. Wei, “CDKL5 Promotes Proliferation, Migration, and Chemotherapeutic Drug Resistance of Glioma Cells via Activation of the PI3K/AKT Signaling Pathway,” FEBS Open Bio 10, no. 2 (2020): 268‐277, https://doi.org/10.1002/2211‐5463.12780. The above article, published online on 21 January 2020, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Miguel A. De la Rosa; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image duplications between this (Figure 3E, 4A and E, 5B and E) and other articles that were previously published or published in the same or following year. Given the extent of the identified issues, the editors have lost confidence in the data presented…
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Taxonomy
TopicsCancer Mechanisms and Therapy · Glioma Diagnosis and Treatment · Protein Degradation and Inhibitors
RETRACTION: Z. Jiang, T. Gong, and H. Wei, “CDKL5 Promotes Proliferation, Migration, and Chemotherapeutic Drug Resistance of Glioma Cells via Activation of the PI3K/AKT Signaling Pathway,” FEBS Open Bio 10, no. 2 (2020): 268‐277, https://doi.org/10.1002/2211‐5463.12780.
The above article, published online on 21 January 2020, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Miguel A. De la Rosa; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image duplications between this (Figure 3E, 4A and E, 5B and E) and other articles that were previously published or published in the same or following year. Given the extent of the identified issues, the editors have lost confidence in the data presented and consider the conclusions of this manuscript substantially compromised.